DeFi blockchains, also known as DeFi chains, power decentralized finance by enabling trustless transactions, lending, and trading without intermediaries. Ethereum, Binance Smart Chain (BSC), and Solana lead the space, supporting smart contracts that run DeFi apps. Avalanche, Fantom, and Polygon offer high-speed, low-cost alternatives. These blockchains provide the backbone for decentralized exchanges, lending platforms, and yield farming, ensuring users have full control over their assets.